Since 1950 the church has been designated a Grade I listed building,[1] and is currently managed by Christian Heritage.

[4] Initially it was a wayfarers' chapel on the Roman road known as Via Devana (this is now Bridge Street).

Part of the ambulatory collapsed in 1841, and the Cambridge Camden Society offered to carry out repairs.

[9] "[2 January 1644 Holy Sepulchre, in Cambridge] We break down 14 superstitious Pictures, divers Idolatrous Inscriptions, one of God the Father, one of Christ and of the Apostles."

Then the north aisle, by that time in poor condition, was also rebuilt, extending it to the same length as the chancel.

[14] The Victorian stained glass in the east window was destroyed by a bomb in the Second World War and was replaced in 1946.

The church is entered by a Norman west doorway with three orders of colonnettes, decorated with scalloped capitals and zigzags, and crenellations in the voussoirs.

[18] Most of the stained glass in the church was introduced during the 19th-century restoration and was designed and made by Thomas Willement and William Wailes.

[16] By 1994 the congregation had grown too large to be accommodated and it moved to the nearby Church of St Andrew the Great.

[19] Holy Sepulchre is open for visitors[5] and contains an exhibition entitled The Impact of Christianity in England,[20] and a study centre known as a scriptorium.

[21] The church hosts concerts, recitals and plays,[22] and arranges courses, summer schools, and lectures.