[5] In the fourteenth century, John de Stratford founded a chantry, which was rebuilt between 1465 and 1497 by Dean Thomas Balshall, who is buried at the church.

The Great and Swell 1 and Pedal 1 divisions are high on the wall above the arch into the tower crossing and face west.

Features of interest aside from the Shakespearean include a sandstone obelisk erected in 1858 in memory of the printer and botanist William Cheshire.

[17] The church still possesses the original Elizabethan register giving details of his baptism and burial, though it is kept by the Shakespeare Birthplace Trust for safekeeping.

The funerary monument was renovated in 1746 through proceeds from a production of Othello, the first recorded performance of a Shakespeare play in Stratford-upon-Avon.

The day after Shakespeare signed his Last Will and Testament on 25 March 1616 in a "shaky hand", William's son-in-law, Thomas Quiney was found guilty in the church court of fathering an illegitimate son, who had recently died in childbirth, by a Margaret Wheler.

Above the grave, a badly eroded stone slab displays his epitaph: Good frend for Iesvs sake forbeare,to digg the dvst encloased heare.Bleste be ye man yt spares thes stones,and cvrst be he yt moves my bones.It has been claimed by at least one textbook author that the warning has served to prevent both the removal of Shakespeare's body to Westminster Abbey and the exhumation of his body for examination.

The inscription states, "Heere lyeth interred the body of Anne wife of William Shakespeare who dep[ar]ted this life the 6th day of Avgv[st] 1623 being of the age of 67 yeares".

[22] In January 2015, planning permission was granted for an extension next to the south aisle of the church to provide a new vestry, toilets and storage space.