Comedian Saiful Apek stars the timid protagonist Hairi who obtains his gecko-like powers quite by accident and becomes a shock to his friend, who also tries his best to adjust to his superpowers while living in the fictional city of Metrofulus.The film received mixed review upon its release.

A sequel, Cicak Man 2: Planet Hitam, was released on 11 December 2008 in Malaysia, Singapore and Brunei following the film's success in the Malaysian box-office.

Suspecting something amiss, Hairi and Danny launch their own investigation and discover that Professor Klon is not only the creator of such viruses, but also has a more sinister plan up his sleeve, backed by his business partners, the Ginger Boys (played by Adlin Aman Ramlie and AC Mizal), who first tend to take revenge on Professor Klon's failed experiment on them; making their senses turn abnormal.

Hairi soon makes use of his new-found powers as "Cicakman" when he saves Tania (Fasha Sandha), Professor Klon's secretary from a threatening situation, and also ends up falling for her.

The visual effects team led by the director, Yusry, used CGI technology to fully realise the fictional city of Bandar Metrofulus (which was based on Kuala Lumpur), the protagonist's super-hero movements and various digital sets.