The city was later settled by French immigrants from Bordeaux and Louisiana led by Don Louis de Clouet on 22 April 1819.

[13] The settlement successively became a town (villa) in 1829, renamed for Asturian-born José Cienfuegos Jovellanos, Captain General of Cuba (1816–19), and a city in 1880.

Many of the streets in old town reflect French origins in their names: Bouyón, D'Clouet, Hourruitiner, Gacel, and Griffo, for instance.

Cienfuegos port, despite being one of the latest settlements established during the colonial era, soon grew to be a powerful town due to the fertile fields surrounding it and its position on the trade route between Jamaica and South American cities to the southeast and the hinterland provincial capital of Santa Clara to the northeast.

Its advantageous trading location on the historically eponymous Bay of Jagua was used by the Cuban sugar oligarchy when a railroad was built between both cities between 1853 and 1860.

[16] The city later became a key industrial center, part of the revolutionary government's "anti-urban" planning policy, with industrial projects including the never-completed Juraguá nuclear power plant, the "Camilo Cienfuegos" oil refinery named for Camilo Cienfuegos, and the "Carlos Marx" cement factory.

Their presence was detected by U-2 reconnaissance aircraft of the United States Air Force that were sent out to monitor the Cuban coastline after a suspicious Soviet request to renegotiate the terms of the Kennedy–Khrushchev agreements of 1962 that were made in the aftermath of the Cuban Missile Crisis, with many American intelligence analysts concluding that the Soviet Navy was planning to construct a submarine base in Cienfuegos.

Despite finishing with the best record at 59–31, the Elefantes lost the semifinals in six games to the eventual champions, the Pinar del Río Vegueros.