[2] After compiling a record of 12–0 (7 KOs) she faced Rhonda Luna for the vacant WIBA featherweight title on December 10, 2005, at the Turning Stone Resort Casino in Verona, New York.
[3] Following three UD victories, she faced Melissa Fiorentino for the inaugural WBC-NABF female super featherweight title on July 7, 2007, at the Joseph L. Bruno Stadium in Troy, New York.
[8] Serrano's next fight came four months later, facing WIBA and WBF female welterweight champion Anne Sophie Mathis, with the vacant WIBF title also up for grabs, on October 1 at the Salle Mermoz in Yutz, France.
[14] She made one successful defence of her WBO title, defeating Paola Torres via UD on May 13, 2017, at the Coliseo Samuel Rodriguez in Aguas Buenas, Puerto Rico.
[15] After an eight-round split decision (SD) victory in a non-title fight against Edina Kiss in October 2017,[16] Serrano moved up to lightweight to challenge former Olympic gold medalist and reigning unified WBA and IBF female champion Katie Taylor.