Cinque Hommes Creek is a tributary of the Mississippi River flowing through Perry County, Missouri.

The early Colonial French name for the creek was "à la viande" or "with meat".

[3] Cinque Hommes Creek was named after Cape Cinque Hommes on the Mississippi River, although this name most likely originates from the Canadian Catholic missionary priest Father Jean Francois Buisson de St. Cosme.

[6] Cinque Hommes Creek empties into the Mississippi River south of Menfro, Missouri in the Red Rock Landing Conversation Area.

[7] Cape St. Cosme or Cape Cinque Hommes - a point on the Mississippi River - was conferred for Father Jean Francois Buisson de Saint Cosme (1667-1702), a missionary priest from the Quebec Seminary of Foreign Missions, who visited the spot in 1698 and erected a cross on Grand Tower.