The arena officially opened in 2000 and was constructed through private donations as part of Xavier University's Century Campaign.

In the spring of 2009, Cintas Center was voted the 3rd "Toughest Place to Play" in a poll conducted by EA Sports.

Cintas Center also hosted the A10 Women's Volleyball Championship in 2010 and is a perennial site for OHSAA boys' basketball state tournament games.

On November 2, 2014, Xavier gave nearby Mount St. Joseph University free use of the arena for the school's women's basketball game with Hiram College.

The game also served as a charity fundraiser for research into diffuse intrinsic pontine glioma, the brain cancer from which Hill was suffering.

[6] On April 13, 2015, the arena hosted a public memorial service for Hill following her death three days earlier.

A practice facility, the Kohlhepp Family Auxiliary Gym, is attached to the arena and is used by the athletic teams, as well as being used as additional event space when needed.