Ciramadol (WY-15,705) is an opioid analgesic that was developed in the late 1970s[1] and is related to phencyclidine, tramadol, tapentadol and venlafaxine.

It has a slightly higher potency and effectiveness as an analgesic than codeine,[5] but is weaker than morphine.

[6] Other side effects include sedation and nausea but these are generally less severe than with other similar drugs.

Michael addition of dimethylamine leads the aminoketone, i.e. 2-[dimethylamino-[3-(methoxymethoxy)phenyl]methyl]cyclohexan-1-one, CID21518320.

Reduction of the ketone proceeds stereospecifically to afford the cis aminoalcohol [51356-58-2] (4).