Citico (also "Settaco", "Sitiku", and similar variations) is a prehistoric and historic Native American site in Monroe County, Tennessee, in the southeastern United States.

On October 16, 1567, an expedition led by Spanish explorer Juan Pardo arrived at a village known as "Satapo" while en route to Coosa, a powerful chiefdom centered in modern northern Georgia.

Research conducted by anthropologist Charles Hudson in the 1980s suggests that Satapo was situated at the Citico site in Monroe County, and that the two names are linguistically related.

The Cherokee believed that a cliff overlooking Citico was once home the "Tlanuwas"— two giant hawks that terrorized people in the valley until a high priest managed to rob their nest and drop their eggs in the water below, where they were devoured by the Uktena.

[3] A Cherokee village thrived at Citico when English explorers and traders began entering the Tennessee Valley in large numbers in the early 18th century.

After the Cherokee aligned themselves with the British in the American Revolution, the colonies dispatched forces under Colonel William Christian and General Griffith Rutherford to subdue the Overhill towns in 1776.

Historian J. G. M. Ramsey reported a conference between militia commander John Sevier and Cherokee Chief Hanging Maw held at the original Citico in 1782 in which the two sides agreed to a truce.

[7] In the late 1780s, a company of scouts led by Captain John Fain was collecting (or stealing) apples at the former site of Citico when they were ambushed by a band of Cherokees.

[8] In the early 19th century, Scots-Irish, English, and German families increasingly began to settle along the isolated ridges and hollows of the Citico Creek Wilderness.

A brief excavation carried out by the Knoxville Chapter of the Tennessee Archaeological Society uncovered several Woodland, Mississippian, and Cherokee artifacts, including shell gorgets and knife blades.