C. freundii is a soil-dwelling microorganism, but can also be found in water, sewage, food, and the intestinal tracts of animals and humans.

[2] C. freundii can also have a positive impact when it comes to the treatment of some cancers; specifically, it has been found to be helpful in killing and treating cervical carcinoma.

[2] C. freundii has an aggressive adherence pattern that has been found in the cells of goats, which has been shown to play a role in its pathogenicity; although, this is not a guarantee of infection.

[4] Due to the phenotypic diversity that C. freundii contains, it makes it very difficult to identify, especially because it is versatile not only in its antigenic and pathogenic behaviors, but also in its cell morphology.

[4] C. freundii contains high degrees of nucleotide diversity due to the two different lineages with deep separation within the taxon.

[9] Unique fitness genes show that numerous metabolic pathways, namely tat-dependent protein secretion, DNA recombination, and repair processes, are all essential for C. freundii’s survival in the circulation system.

However, since swimming is rarely observed in the tatC mutant, it is possible that flagellar function is retained to some extent.

C. freundii is also a nitrogen-fixing bacteria, a process demonstrated in the living tissues of sassafras trees.

[10] Toxigenic C. freundii appears to be rare, and its main influence on human health is as an opportunistic pathogen.

[10] As such, C. freundii causes a wide range of illnesses, including infections of the urinary system, respiratory tract, wounds, circulation, and other sites in immunocompromised patients.

[4] Phenotypic changes that are reversible from the parental strain of atypical C. freundii have been identified as a result of a fluctuating environment.

[4] A possible explanation for this is the hypothesis that the offspring from a bacterial strain will be produced with varying degrees of phenotypic changes in order to increase the rates of survival in challenging conditions.