City of Hope is a private, non-profit clinical research center, hospital and graduate school located in Duarte, California, United States.

[citation needed] In the late 19th and early 20th centuries, the spread of tuberculosis, also known as "consumption", was a growing concern in the United States and Europe.

In 1913, the Jewish Consumptive Relief Association was chartered in Los Angeles, California, with the intent of raising money to establish a free, non-sectarian sanatorium for persons from throughout the United States diagnosed with tuberculosis.

[3] The sanatorium was nicknamed "the city of hope", and grew in size for several decades, continuing to raise funds, construct permanent facilities, hire doctors and treat increasing numbers of patients.

From 1983 to the present, City of Hope continued to grow, expanding its Duarte campus with additional patient care, research and support facilities.

As such, City of Hope's programs include the fields of brain, breast, gastrointestinal, gynecologic, thoracic and urologic cancers, as well as leukemia, lymphoma, and diabetes.

[7] In 1978, City of Hope researchers Arthur Riggs and Keiichi Itakura, working with Herbert Boyer of San Francisco–based biotechnology corporation Genentech, Inc., became the first scientists to produce synthetic human insulin.

On August 13, 1999, City of Hope sued Genentech for allegedly cheating it out of its fair share of the profits from products based on the Riggs-Itakura patents.

Southern California community practice clinics are located in Antelope Valley, Arcadia, Corona, Glendale, Glendora, Huntington Beach, Irvine Sand Canyon, Long Beach, Mission Hills, Newport Beach, Palmdale, Pasadena, Riverside, San Bernardino, Santa Clarita, Sherman Oaks, Simi Valley, South Bay, South Pasadena, Temecula, Thousand Oaks, Torrance, Upland, West Covina, West Hills and Wildomar.

Research conducted at the institute has contributed to discoveries in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies.

[citation needed] City of Hope Center for Biomedicine & Genetics is a manufacturing facility specializing in the production of pharmaceutical-grade materials.

City of Hope has 40 temporary, on-site residential housing units for patients and their caregivers, with integrated hospice and palliative care.

City of Hope secures funding from a mixture of sources, including patient revenue, private donations, foundation support and federal research grants.