Only in 1959 the Municipality managed to acquire the building and to start, under the direction of the architect Amos Edallo, important redevelopment works, in order to allocate the former convent to a cultural use.

In addition to the figure of Edallo, it can be remembered in particular the involvement of Winifred Treni De Gregory and the painter Gianetto Biondini, who edited the craft section but especially the artistic one, one of the most substantial of the museum heritage.

[5] The following year was established the section of organaria art, homage to the tradition of the city of Crema in the realization of pipe organs and the first Italian museum dedicated to this theme[6][7] It shows fossils and remains of animals like deer, bison and aurochs found in the area and dating back to the Paleolithic Era, but also items belonging to the Neolithic Era, to the Bronze and Iron Ages, to the Roman and medieval period.

Some papers from the Habsburg Era are ideally followed by a rich repertoire of memorabilia, documents and memories of the Risorgimento, witnesses of the presence in Crema of important personalities of the time, such as Enrico Martini and Vincenzo Toffetti and of the visits to the city made by Giuseppe Garibaldi in 1862 and Vittorio Emanuele II in 1859.

With regard to the Great War, there are significant relics of General Fortunato Marazzi and Infantry Major Umberto Fadini, Cremaschi characters who had important roles in the conflict.

Particularly noteworthy are the paintings Enrico Martini, diplomat in Russia by Karl Pavlovič Bryulov and Gli ostaggi di Crema by Gaetano Previati, owned by the Brera Academy of Fine Arts and stored at the Cremasco museum.

In contrast, some paintings by Palma il Giovane, Guercino, Bronzino, Fra Galgario, Magnasco, Cignaroli and, more recently, a Portrait of a Man by Domenico Induno are unrelated to the Cremasco context.