Clarence Lorenzo Simpson Sr. (1896–1969) was a Liberian politician who served as the 22nd vice president and the speaker of the House of Representatives.

[1] Clarence Lorenzo Simpson was born in Liberia to Alpha D. Simpson, an Americo-Liberian and Kamah Gray, a Vai woman who was the grand-daughter of the Great Vai King Long Peter from Grand Cape Mount, Liberia .

Before becoming Secretary of State, Simpson had served as Post Master General and Speaker of the Liberian House of Representatives from 1931 to 1934.

[2] After leaving the Department of State in 1943, Simpson was one of the six candidates in that year's election.

Simpson also held the following positions: Ambassador to the Court of St. James, London, England; Ambassador to the United States, Washington, D.C.; Grand Master of Masons, Republic of Liberia, and Head of the National True Whig Party of Liberia, a political party that ruled Liberia for over 100 years.