The textbook reflected Manion's belief that government's duty was to guarantee a decent standard of living and was largely supportive of President Franklin D.

[5] Manion also began to distance himself from the Democratic Party after the Supreme Court's 1942 decision in Wickard v. Filburn, which he believed expanded the definition of "interstate commerce" beyond reasonable limits.

Eisenhower instead appointed Manion as chairman of the Intergovernmental Relations Committee, a commission charged with reviewing the balance of power between federal and state governments.

[7] After leaving the Eisenhower administration, Manion founded and co-chaired (with Robert E. Wood) "For America", an organization pledged to "enlightened nationalism" and combat "[America's] costly, imperialistic foreign policy of tragic super-interventionism and policing this world single-handed with American blood and treasure.

"[8] He also began a weekly radio broadcast from his hometown of South Bend, Indiana, titled The Manion Forum of Opinion.

[12] In 1960, he and Representative William Jennings Bryan Dorn recruited Orval Faubus to run on the same ticket in the South.

[12] He also spent the year campaigning for an effort to draft Barry Goldwater for the Republican nomination, including publishing the best-selling book Conscience of a Conservative, ghost-written for Goldwater by L. Brent Bozell Jr.[13] Manion's son, Daniel Anthony Manion, served as a federal judge and member of the Indiana Senate.