[4] He began working for George L. Hooper at his Village Apothecary Shop pharmacy, founded in 1838 by Dr. Galen Hunter, at 104 Sixth Avenue (today, number 414).

In 1904, he moved the business to 106–108 Sixth Avenue,[3][5] two doors to the north of its original location,[6] and expanded it twice over the next forty years.

His chief clerk remained with the business from its founding until at least the turn of the century, a period of twenty years.

[4] In 1900, he put his success down to two factors: keeping his capital invested in his company, and employing the best people as clerks and assistants.

[4] In 1924, Bigelow unveiled inside the store's main entrance a large bronze tablet commemorating the 85th anniversary of the incorporation of the business.