It was unofficially known as La Clark by the Puerto Ricans that lived there arriving from the steel mills of Indiana and rural migrant camps.

Many original members of the Young Lords, a former street gang that transformed into a Latino civil and human rights movement, were sons and daughters of these immigrants and grew up in La Clark.

At the intersection of Clark and Addison is Wrigley Field, home of the Chicago Cubs baseball team and also occasionally used as a concert venue.

Further to the south, Clark Street borders Lincoln Park for 0.6 miles until it reaches North Avenue and the Chicago History Museum.

Then it continues over the Chicago River at the Clark Street Bridge and through the Loop, where it passes the Thompson Center and its Monument with Standing Beast.