It serves the north-western suburb and town of Clarkefield, in Victoria, Australia.

It was renamed to Clarkfield on 11 January 1926, then finally was given its current name of Clarkefield on 23 February 1926.

The station, like the township itself, was named after local pastoralist, businessman and philanthropist, Sir William Clarke.

[2] In 1977, the connections from the refuge siding to the up line was spiked out of use, with the auxiliary frame also abolished around this time.

This is to allow services in the peak direction of travel to use the single 160 km/h track that was upgraded in 2006, as part of the Regional Fast Rail project.