It serves the north-western suburb and town of Macedon, in Victoria, Australia.

[1][2] Initially opened as Middle Gully, the station was given its current name of Macedon on 1 April 1870.

[2] In 1994, the Victoria Street level crossing, which was located at the down end of the station, was closed to road traffic except for emergency access vehicles.

[2] In March 2014, the platforms were extended to accommodate longer trains.

This is to allow services in the peak direction of travel to use the single 160 km/h track that was upgraded in 2006, as part of the Regional Fast Rail project.