Clarksdale is a city in southwest DeKalb County, Missouri, United States, located along the Little Third Fork of the Platte River.

[5] The community was named after John F. Clark, the original owner of the town site.

[6] According to the United States Census Bureau, the city has a total area of 0.32 square miles (0.83 km2), all land.

The racial makeup of the city was 98.9% White, 0.4% Native American, and 0.7% from two or more races.

41.9% of all households were made up of individuals, and 17% had someone living alone who was 65 years of age or older.

34.5% of all households were made up of individuals, and 19.7% had someone living alone who was 65 years of age or older.