Osborn is a city in northern Clinton and southern DeKalb counties in the U.S. state of Missouri.

[4] The Clinton County portion of Osborn is part of the Kansas City, MO–KS Metropolitan Statistical Area, while the DeKalb County portion is part of the St. Joseph, MO–KS Metropolitan Statistical Area.

Osborn got its start following the construction of the Hannibal and St. Joseph Railroad through that territory.

[5] Col. Osborn, born in Sangerfield, New York on May 9, 1809, was an Oneida National Bank and Trust Company of Central New York commissioner and farmer who, in 1845, relocated to Missouri, where he partnered with the Hannibal and St. Joseph Railroad Company, the firm that constructed the Hannibal and St. Joseph Railroad.

Osborn is home of the Wildcats and proudly sports the orange and green.

According to the United States Census Bureau, the city has a total area of 0.57 square miles (1.48 km2), all land.

The racial makeup of the city was 98.90% White, 0.22% African American, and 0.88% from two or more races.