Clarkson is an unincorporated community in Middleton Township, Columbiana County, Ohio, United States.

Clarkson was platted in February 1816 by Robert Hanna, who moved there in a conestoga wagon with his wife.

[4][5][6] In 1817, James Monroe, while President of the United States, visited his cousin, Catherine Hanna, in Clarkson.

He established the first Standard Oil dealership in Ohio, holding vendor's license Number 1.

[4][8] Bank robber Pretty Boy Floyd was shot and killed by FBI agents in a corn field near Clarkson in 1934.