The comic had 64 pages, and the front cover depicted many of the characters in one group activity, drawn from September 1997 to May 2006 by Anthony Caluori.
The reprints inside were prefaced with a contents page ("Classic Contents") and until 2007 were followed by an advert for the next month's issue, with the back cover showing original strips starring Roger the Dodger, Little Plum, Plug, Beryl the Peril, and Desperate Dan amongst others, drawn by Gordon Bell, Anthony Caluori, or Keith Reynolds.
In July 2004 Classics from the Comics celebrated its 100th issue, revamping the front cover at the same time, changing the logo from a plain serif font to a sans-serif one with a 3-D effect.
It featured the oldest (Ping the Elastic Man and Deep Down Daddy Neptune, 1938), and most recent stories (specifically the picture of Dennis, Gnasher, Wallace & Gromit from the Beano printed only the previous day; the most recent actual story was "Crazy for Daisy" from 2003) ever used.
For this issue, the usual Korky roundel was replaced with the logo from the 70 Years of Fun collector's edition.