Attached to the university are the Hospices Civils de Lyon, including the 'Centre Hospitalier Lyon-Sud', which is the largest teaching hospital in the Rhône-Alpes region and the second-largest in France.

[3] The university is not located on a single campus but has departments and other facilities distributed across several key sites throughout Lyon and the wider region.

The LyonTech-la Doua campus located north of Villeurbanne and east of Lyon's Parc de la Tête d'Or hosts the administrative headquarters of the university as well as its Faculties of Science and Technology and of Sport Sciences.

A second key site, the Lyon Health East Campus, is located in the eighth arrondissement next to the Edouard Herriot hospital and the Vinatier medical centre.

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