Born in Amboise, Chappuys was a valet and librarian for François I, then secretary to cardinal du Bellay.
He entered the priesthood and was appointed high dean of the Chapter of Rouen by the King.
In addition to his court poems, he composed blasons,[2][3] epigrams, epistles, and songs.
He was linked to Mellin de Saint-Gelais and Marot, who considered him to be one of the good poets of his time; however, his name remained long forgotten.
Wilhelm Killmayer set one of his poems in his song cycle Blasons anatomiques du corps féminin in 1968.