After the initial colonization effort, it is known that Claude engaged in fur-trading activities in the Penobscot Bay area.
It is believed that Fort Pentagouet, a combined trading post and fishing station which he built, was the first permanent settlement in present-day New England.
We know that about 1626, Claude de La Tour had to abandon the area to the Plymouth colony.
Claude was eventually convinced by his son Charles to return to Cap de Sable and French allegiance.
He was in receipt of a large land grant and Fort Pentagouët itself by the French Crown although it does not appear that he took residential possession of it.