Rey’s family owned a prosperous printing works which went bankrupt in 1847.
One of his uncles, the owner of a vineyard producing Morgon, offered him employment.
Impassioned by entomology, he began a collaboration with Etienne Mulsant (1797–1880) who was then working on Histoire naturelle des coléoptères de France - Natural History of the Beetles of France.
The Coleoptera are not the only study of Mulsant and Rey since they also worked on naturelle des punaises de France -the Natural history of the True Bugs of France.
In addition to these publications, Claudius Rey wrote many articles on Coleoptera in journals .