Claymont station was originally built by the Pennsylvania Railroad as a commuter rail stop between Philadelphia and Wilmington.

The new station is located 1⁄2 mile (0.80 km) north of the former station at the former site of Evraz Claymont Steel, which is being redeveloped into a mixed-use office, commercial, and light industrial development, and will have connections to area roads, public transportation, and pedestrian and bicycle facilities.

[9] Construction on the Claymont Regional Transportation Center began in spring 2019.

The Claymont Regional Transportation Center, which was dedicated in honor of former State Senator Harris McDowell III in 2022, features two high-level side platforms with a pedestrian bridge over the tracks, a parking garage with 464 spaces, an outdoor parking lot with 343 spaces, and electric vehicle charging stations.

[12] The Claymont Regional Transportation Center opened for train and bus service on December 4, 2023.