Clayton is a small town in Liberty Township, Hendricks County, Indiana, United States.

In 1829 a little town in Liberty Township was named "Clayville", honoring Henry Clay, the Kentucky statesman.

[5] The name was changed to "Clayton" in 1858 because another Clayville already existed in Dubois County.

The first two houses in Clayton were built by Thomas Potts and Lewis T. Pounds, and Parker & Foote was the first store.

George Wills built the first hotel, and John Miles and James Worrell developed the first flouring mill.

By the early 1900s, the town had electric service, supplied by the Danville Light, Heat and Power Co.

Indiana State Road 39 is the main road through the town, leading north 5 miles (8 km) to Danville, the county seat, and southeast 2 miles (3 km) to U.S. Route 40 at Belleville.

Interstate 70 passes 6 miles (10 km) south of Clayton, with access from State Road 39.

Downtown Indianapolis is 24 to 28 miles (39 to 45 km) east of Clayton, depending on which highway is taken.

[6] Clayton is known for its annual Fall Festival sponsored by the Clayton Community Association in September, featuring horse pulls, tractor pulls, live bands, food, kids' games, bingo, a parade and more.

Clayton also sponsors the annual "Triple F Ride" in June which is a non-profit bike rally starting in Lambert Park.