Clayton Andrews (born May 15, 1978) is a former left-handed pitcher in Major League Baseball.

Andrews was taken in the third round of the 1996 amateur draft by the Toronto Blue Jays.

His only major league appearances came with the Blue Jays in the 2000 season, where he racked up an ERA of 10.02 in 20 2/3 innings.

His lone major league win came on May 28 against the Detroit Tigers at Comerica Park where he pitched 4 hitless, scoreless innings of relief in a 12-7 Blue Jays victory.

This biographical article relating to an American baseball pitcher born in the 1970s is a stub.