No written records about Cleopatra V exist after 57 BC and two years later Berenice IV was overthrown by Ptolemy XII, his throne restored with Roman military aid.

They received divine worship as theoí Philopátores kai Philádelphoi (father-, brother- and sister-loving gods).

[12] Cleopatra’s Egyptian titles, found primarily at Edfu and Philae, include Daughter of Re, Female Ruler, and Mistress of Two Lands.

Should she really have died that early, then the Cleopatra Tryphaena who is mentioned — after the expulsion of Ptolemy XII — as co-ruler of Egypt (together with Berenice IV) in 58 and 57 BC, and died around 57 BC, must be her daughter, numbered by some historians as Cleopatra VI Tryphaena.

[15][16] On the other hand, there is a dedication on the Temple of Edfu from December 5, 57 BC that inscribes Cleopatra Tryphaena's name alongside Ptolemy XII's (who however was not present in Egypt at that time), which would have meant the king's wife rather than daughter and would be unlikely had Ptolemy XII's wife really died already twelve years earlier.

[28] Part of his argument is based on Strabo's mention of Ptolemy XII's having only three daughters, Berenice being the only legitimate one.

[28] But as Grant notes that, of all the attacks on Cleopatra VII, her being illegitimate is not among them, and that it is only mentioned in a casual statement by Strabo.

[30] In 55 BC, upon his return to Egypt from exile with Roman military aid, Ptolemy XII had his rival daughter Berenice IV executed for usurping his throne.