Cleveland competes in the National Premier Soccer League (NPSL) as part of the Midwest Region's Great Lakes Conference.

Through six seasons, Cleveland SC has won three conference and two region championships, has never missed the NPSL playoffs, and has appeared twice in the U.S. Open Cup.

Notable players to have appeared for the club include Puerto Rico international Ryan López, as well as Ohio natives Riley Grant and Ben Fitzpatrick, while Louie Rolko served as an assistant coach.

[9] In conjunction with local designers, a crest and kits featuring an orange and black color combination were launched in mid-March, less than a month before the club's inaugural match.

[7] The first-ever league match in CSC history took place on May 19, 2018, ending in a 2–0 victory over Rochester Lancers courtesy of goals from Declan McGivern and American futsal international Antonio Manfut.

[11] After a second-place finish in the Midwest-East, the club qualified for the playoffs and defeated Erie Commodores in the quarterfinals before falling to AFC Ann Arbor in the regional semifinals.

[14] The club crest was designed by Mike Kubinski of Cleveland Clothing Co., a local T-shirt company headquartered in Lakewood, Ohio.

[16] Cleveland SC hosted its first round match in the 2023 U.S. Open Cup at Drive Morris Stadium in North Olmsted, Ohio.

North Olmsted High School, the primary tenants of the stadium, play football, soccer, and track and field at Drive Morris.

[9] The head coach of the Blue Streaks men's soccer program at the time, Hector Marinaro, helped secure the stadium availability for CSC.

[21] The debut match at the stadium was on May 5, an international friendly against Mexican side Monarcas Morelia Reserves as part of the Neighbor Nations Showdown.

[23] Cleveland SC hosted two NPSL playoff games at the George Finnie in 2021, as well as the club's U.S. Open Cup debut, a first round victory against Chicago FC United in March 2022.

[37] Osborne, a former player for the Charleston Golden Eagles and West Virginia Chaos, also served as an assistant coach for the Notre Dame Falcons during his time in charge of Cleveland.

[42] After Dunne's departure, Cleveland hired Vlad Muresan, the head boys soccer coach at the Hawken School, as his replacement.

[43] Muresan, a former player for Ohio Vortex and Akron Summit Assault, led the club to a Rust Belt Conference title and a return to the Open Cup in his first year in charge.

[47] In May 2019, Cleveland SC acquired the rights to Rubber City FC, a planned expansion team in the Northern Ohio Soccer League (NOSL).

[55] Separated by less than 50 miles (80 km), Cleveland SC has a rivalry with fellow Ohioan NPSL club FC Columbus.

[56] The derby is named after Grandpa's Cheesebarn, a landmark business that sits roughly halfway between the two cities on Interstate 71 in Ashland, Ohio.

[7] When the clubs were founded, they were placed into different conferences in the NPSL, so the derby began as a series of preseason friendlies: each team claimed a victory in 2018 and they played to a 1–1 draw in 2019.

Due to NPSL scheduling, which does not include inter-conference play during the regular season, Cleveland has built up competitive rivalries with Great Lakes Conference opponents Erie Commodores and Steel City FC.

[64] AFC Cleveland claimed the inaugural trophy in 2012, but Detroit won four in a row, before switching conferences in 2016 then moving leagues to the National Independent Soccer Association in 2020.

[65] Although the derby was dormant for three years, Cleveland SC continued to face Buffalo in league play and defeated Detroit in the 2019 Midwest Region final.

That record includes one international friendly, a victory against Mexican side Monarcas Morelia Reserves in 2019 as part of the Neighbor Nations Showdown.