According to the inventory after his death, he traded in tea, tobacco, sugar, cotton, spices, herbs, and dyes like indigo and dragon's blood.

The brothers split in 1713, before or after the bank arranged a loan to Charles VI, Holy Roman Emperor, and to Augustus III of Poland.

[5] The result was Linnaeus' book Hortus Cliffortianus, whose publication costs were paid by George Clifford III.

The Cliffords regularly lent money to banks in Saint Petersburg and Moscow, the English and Danish governments, and owned plantations in Suriname.

In May 1772, with £15,000, the Cliffords and Muilman representing Van Seppenwolde organised an exchange circuit in the hope of making a profit on rising EIC shares.

Both Clifford's sons tried to plug the gap after their father's death by privately undertaking bold speculation in the EIC and the Bank of England.

In December the company went bankrupt during the Crisis of 1772 after price overshooting on the Amsterdam and London stock market, bringing down a number of other bankers and their firms.