[7] Following their rebranding as Cliftonville Ladies,[8] the club became founding members of the Women's Premiership in 2016, as a result of the Northern Ireland Football League's decision to take over the running of the WPL.

[13] In June 2022, six Cliftonville players, including national team captain Marissa Callaghan, were called up to the 23-women Northern Irish senior squad that took part in the UEFA Women's Euro 2022.

[20][21] In June 2023, Cliftonville were one of the five football teams from the Irish League that took part in the inaugural edition of the All-Island Cup,[22][23] where they reached the final,[24][25] before finishing as runners-up following a defeat to Galway United.

[29][30] In September 2023, Cliftonville made their debut in the UEFA Women's Champions League against Benfica in the first qualifying round.

[3][31] On 6 September they suffered an 8–1 away defeat to the Portuguese side: however, Caitlin McGuinness scored the club's first goal ever in a European competition in the process.