The facility specializes in genetic problems of the plain sects, such as the Amish and Old Order Mennonites.

[3] The Clinic for Special Children was founded by the Plain community with Dr. D. Holmes Morton and his wife, Caroline in 1989.

[2] The original clinic building was raised by the Plain community in Strasburg, Pennsylvania and completed in 1990.

[4] In 2024, the organization moved to a new facility in Gordonville, Pennsylvania after a successful $13.3 million capital campaign.

[5] In addition to patient care facilities, the Clinic also houses its own laboratory, providing rapid biochemical and molecular genetic testing.