Clinical Chemistry is a peer-reviewed medical journal covering the field of clinical chemistry.

It is the official journal of the American Association for Clinical Chemistry.

The journal was first published in 1955 on a bi-monthly basis "to raise the level at which chemistry is practiced in the clinical laboratory"; monthly publication commenced in 1964.

[1] The editor-in-chief is Nader Rifai (Harvard Medical School).

According to the Journal Citation Reports, the journal has a 2020 impact factor of 8.327.