Clinical and Vaccine Immunology (CVI) was a peer-reviewed journal published by the American Society for Microbiology.

The journal publishes primary research articles, editorials, commentaries, minireviews, and case reports.

Through its "Global Outreach Program", free online access is available to qualified microbiologists in eligible developing countries.

Under Plaeger's leadership, and in response to ASM members' feedback, the journal expanded its scope to include the growing field of veterinary and human vaccines.

It has been named a Rising Star among journals in the field of Immunology in Essential Science Indicators from Thomson Reuters for several months during 2010 and 2011.