Clio (pronounced CLY-oh) is a town in Marlboro County, South Carolina, United States.

[7] According to the United States Census Bureau, the town has a total area of 0.8 square miles (2.1 km2), all land.

As of the census[3] of 2000, there were 774 people, 302 households, and 192 families residing in the town.

There were 339 housing units at an average density of 405.8 per square mile (156.7/km2).

33.8% of all households were made up of individuals, and 15.6% had someone living alone who was 65 years of age or older.