Clofedanol has local anesthetic, antispasmodic, and antihistamine properties,[1] and may have anticholinergic effects at high doses.

[2] Adverse effects may include irritability, drowsiness, nightmares, vertigo, nausea or vomiting, visual disturbances or hallucinations, and urticaria.

[3] Unlike many other antitussive drugs such as dextromethorphan, it binds poorly to the sigma-1 receptor.

It was formerly sold over-the-counter in the United States under the trade name Ulo, as a syrup with a dosage of 25 mg/5 mL.

GM Pharmaceuticals owns the patents to 113 combinations with Chlophedianol and was the first company to launch the cough suppressant in the United States.