The Mater Dei Institute of Education was established in 1966 on part of the Clonliffe College campus, and used some of the resources of the former seminary, such as the sports grounds, until its closure in 2016.

[11] 2015 saw the Pathways - Exploring Faith and Ministry adult education course, previously run for 30 years by the nearby All Hallows College, transferred to the Diocesan Centre and delivered in Clonliffe.

[12] From 2021 the Pathways programme is being delivered from the Mater Dei Centre for Catholic Education (MDCCE), in DCU St. Patrick's College, Campus.

The sale, according to the Archdiocese, will create "social, affordable and private housing and sports facilities for children and young adults as well as a hotel and commercial opportunities providing employment for people living in the area.

The archive contains the papers of eleven Archbishops of Dublin, a number of auxiliary bishops and of Bartholomew Woodlock the second president of the Catholic University of Ireland.

The College participated in Culture Night 2013 where its archives and artwork were on display to the general public, as well as recitals of music and a talk on the 1913 Lockout.

[21] A number of public figures such as poet Denis Devlin and former TD, government minister and Mayo football captain Seán Flanagan, were seminary students at Clonliffe.

Presidents of the College have included Bishop Thomas Joseph Power (1859–1870), Michael Verdon (1870–1879), Canon Bartholomew Fitzpatrick, John Waters (1915-1921), Matthew S. MacMahon, Patrick Dargan, Jerome Curtin, Edward Gallen (1952-1955),[22] Cathal McCarthy (1955-1964), Joseph Carroll (1964-1968), also president of Mater Dei, Brendan Houlihan, Owen Sweeney, John J Greehy (1980–1983), and Peter Briscoe (1989-2000).