Clotworthy Skeffington, 1st Earl of Massereene PC (I) (1715 – 14 September 1757) was an Anglo-Irish peer.
He succeeded to his father's title in 1738 and assumed his seat in the Irish House of Lords.
Massereene married firstly Anne Daniel on 16 March 1738; however, she died two years later.
He married secondly Anne Eyre (granddaughter of Sir Willoughby Hickman, 3rd Baronet) on 25 November 1741, and together they had six children.
On his death he was succeeded by his eldest son, also named Clotworthy Skeffington.