[6][4] The team competed in many regional tournaments within Mexico, and for a time, also in the Women's Premier Soccer League of the United States.

On July 29, 2017, led by technical director Andrea Rodebaugh, the Xolas debuted in Apertura 2017 on the road against Club América, a match they lost 1–0.

Tijuana had been drawn into Group 2, along with América, Pachuca, Toluca, Pumas, Monarcas, Cruz Azul, and Veracruz.

Mexican-American forward Renae Cuéllar is the top scorer in club history, with 76 career goals for the Xolas.

[9] As of 14 July 2024[update][2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.