[6][4] The team competed in many regional tournaments within Mexico, and for a time, also in the Women's Premier Soccer League of the United States.

On July 29, 2017, led by technical director Andrea Rodebaugh, the Xolas debuted in Apertura 2017 on the road against Club América, a match they lost 1–0.

Tijuana had been drawn into Group 2, along with América, Pachuca, Toluca, Pumas, Monarcas, Cruz Azul, and Veracruz.

During Clausura 2023, the club recorded their first ever victory in the Liguilla phase after beating Rayadas 2–0 at home in the first leg of the quarterfinals.

[9] As of 14 July 2024[update][2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.