Established in 1924, the club hosts a large variety of sports disciplines such as basketball, basque pelota, fencing, field hockey, futsal, rugby union, swimming and water polo.

Universitario's arch-rival is neighbour club Gimnasia y Esgrima (also known for its acronym "GER").

The colors adopted were related to the representative color of each university, therefore they were red (Medical school), green (Engineering), blue (Law) and yellow (Economics), according to the act of foundation of the club.

[1] Universitario was one of the most participative sports club in Rosario, having been founding member of some of governing bodies in the city, such as Rugby, Basketball, Athletics and Field Hockey Associations, as well as the Santa Fe Province Fencing Federation.

Athletics would become the first sport practiced at the club, later followed by fencing, football, swimming, rugby union, basketball and field hockey.