The first meetings were at Miguel Ise's (one of the founders) home, with Cayetano Apilli, Segundo Piñeiro, Eduardo Cela, Manuel Luque, Emilio Roer, Héctor Castellano, Santos Mordibucci, Vicente Otero, José Casajuana, Vicente Iglesias, Tomas Troncoso, Domingo Gullacci, Tersilio Costa, Ricardo Valli, Manuel Otero, José García, Fernando Cela, Acrata Cuervo, Ramón Mielgo, Marcelo Rodríguez, Pedro Genchi, Argido Robledo, Valerio Spegardi, Marcos Fenoglio, Santiago Pedrocchi, Antonio Estévez, Miguel Pi, Víctor Lombardi, Marcos del Río, Juan Cuadrado, Ángel Genchi, Arturo Mongrovejo, Cayo Iglesias, Feliz Muñoz, Osiris Troncoso and Enrique Chitolini.

[citation needed] After some friendly matches, in 1925 Villa Mitre joined Liga del Sur having its first field in Rivadavia and Parera streets.

On October 2, 1927 it was promoted to the first division of the league, winning against Rosario Puerto Belgrano 2–1, with Eloy de Robles as coach.

The Liga del Sur want to ascend both teams, but Soraiz, the Villa Mitre's president, said that his club will enter to first division for the front door and rejected the linguistic offer.

Finally, Villa Mitre obtains the championship in 1929, and starts in first division next year playing a match with Club Dublin.

Historically, Villa Mitre had two great periods of success: In 1944 the "tricolor" won everything: Local Championships brightly and, later, were provincial champions, losing only to Newell's Old Boys from Rosario.