Cluses (French pronunciation: [klyz]; Arpitan: Clluses) is a commune in the Haute-Savoie department in the Auvergne-Rhône-Alpes region in southeastern France.

Travelers crossing the bridge soon stimulated trade in the area, and the first village was born at the center of the "cluse" (a narrow valley), situated between the mountains and the Arve River.

Watchmaking now accounts for only a small part of Cluses' industry, though the town continues to serve as a high-tech centre for precision engineering and design of advanced technical products.

Somfy S.A., a manufacturer of controls and motors for awnings, roller shutters, window coverings, and projection screens, is the largest company still located in the city.

Sardagne, Centre-ville (downtown), Messy, the Ewües I and II, the Noiret, Marzan, Ponthior, Curzeilles, St Vincent, and Saint Nicolas.