A former junior US Open champion and top 10 singles player, she won two WTA Tour titles, both at the Rosmalen Grass Court Championships.

[citation needed] Vandeweghe made her WTA Tour debut at the 2006 San Diego Classic at the age of 14, losing in the first round to Kateryna Bondarenko.

At the US Open, where she would go on to win the girls' singles title, Vandeweghe made her debut in the main draw of a Grand Slam with the wildcard she received from reaching the finals of the USTA junior national championship.

[9] In 2009, Vandeweghe obtained an invitation from the Hong Kong Tennis Patrons' Association to play the JB Group Classic exhibition tournament with compatriot Venus Williams and Argentine Gisela Dulko in January.

At the San Diego Open in August, Vandeweghe made her first deep run at a WTA tournament, beating Gisela Dulko and then Vera Zvonareva for her first top-ten victory.

[10] Towards the end of the season, Vandeweghe won first career match in the main draw of a Grand Slam tournament at the US Open, defeating world No.

Given a wildcard into the Indian Wells Open, Vandeweghe earned her first WTA singles win of the year, beating Alexandra Cadanțu 6–4, 6–0 before losing to eighth seed Petra Kvitová 1–6, 3–6.

There, Vandeweghe beat Marina Erakovic, Anastasia Pavlyuchenkova, and Samantha Stosur before losing to eventual champion Serena Williams in the fourth round.

At the French Open, Vandeweghe won her first-round match for the first time in Paris, beating Iveta Benešová in straight sets before losing to Ekaterina Makarova in the second round.

In the main draw, Vendeweghe beat Marina Erakovic, Vania King, Garbiñe Muguruza, Klára Koukalová in the semifinals, and Zheng Jie in the final.

Vandeweghe achieved her best Grand Slam result at the Australian Open, where she made the third round for the first time after victories over Francesca Schiavone and Samantha Stosur, falling to Madison Brengle.

Vandeweghe is now coached by Craig Kardon, who has previously worked with star players like Martina Navratilova, Lindsay Davenport, Jennifer Capriati, and Ana Ivanovic.

She commenced her season at the Auckland Open, where she was the seventh seed but lost to her compatriot and good friend Irina Falconi in the first round 7–5, 4–6, 3–6, despite being up a break in the final set.

However, Vandeweghe enjoyed some success in women's doubles, where she and her partner, Anna-Lena Grönefeld, reached the quarterfinals and losing to world number ones Sania Mirza and Martina Hingis in three sets.

Vandeweghe teamed up with Romania's Horia Tecău in the mixed doubles event where they made the final, falling just short to Elena Vesnina and Bruno Soares.

At the Qatar Open, Vandeweghe made it to the third round, with straight-set wins over Kirsten Flipkens and Belinda Bencic, obtaining her first top-ten victory of 2016.

In March, Vandeweghe made the third round at Indian Wells, beating Kiki Bertens and Svetlana Kuznetsova before losing to Jelena Janković for the second time in 2016.

She beat Indy de Vroome, Nao Hibino, Evgeniya Rodina, Madison Brengle, and finally, Kristina Mladenovic, 7–5, 7–5, to win the title.

3 and top seed Agnieszka Radwańska, Christina McHale and Yanina Wickmayer, before losing to Barbora Strýcová and thus ending her eight-match winning streak.

Vandeweghe struggled for the remainder of the 2016 season, registering just two more wins; over Nicole Gibbs in Stanford at the Bank of the West Classic, where she was the fourth seed, and over Sara Errani in Cincinnati.

She then defeated seventh seed Garbiñe Muguruza in straight sets to advance to her first-ever semifinal of a Grand Slam, where she went head-to-head with the 2003 finalist Venus Williams.

Vandeweghe also became the fourth North American woman other than the Williams sisters to make the semifinals at an Australian Open in five years, following Sloane Stephens (2013), Bouchard (2014), and Madison Keys (2015).

She beat Mona Barthel in straight sets in the first round, then continued with straight-set victories over Tatjana Maria and American compatriot Alison Riske.

1, Karolina Plisková in straight sets to advance to her second major semifinal, where Keys defeated her, thus being denied of the chance to reach her first Grand Slam final.

[18][19] Shortly after, Vandeweghe revealed that she had suffered from a severe virus during the Australian Open and was ordered by her doctor to limit her travel, due to recovery.

The pair won their first doubles title together, with notable wins over fourth-seeded Tímea Babos and Kristina Mladenovic in the first round, top-seeded Ekaterina Makarova and Elena Vesnina in the semifinal, and second-seeded Barbora Krejciková and Kateřina Siniaková in the final.

But the US Open became a turning point for Vandeweghe when she and Ashleigh Barty made a big surprise by winning their first Grand Slam title in doubles.

On their way to the final, the pair won their matches in two sets, including notable wins over third-seeded Andrea Sestini Hlavacková and Barbora Strýcová in the third round and top-seeded Krejciková and Siniaková.

Vandeweghe revealed after her comeback match that her ankle problem was diagnosed as Complex Regional Pain Syndrome, a nervous disease in the system which occurs after an injury.

136 at the inaugural Texas Open in Austin, she reached the main draw as lucky loser and won her first-round match against Robin Montgomery.