At Târgu Mureş, Romania, Makarova claimed her second $10k title without dropping a set, defeating Simona Matei in the finals.

In Moscow as a wildcard in the qualifier, she earned her first top 100 victory over Tatiana Perebiynis and Marta Domachowska, but lost to compatriot Anna Chakvetadze.

At an ITF event in Moscow, she reached the final defeating Vesna Manasieva in the quarterfinals and Anna Lapushchenkova in the semifinals, before falling to Evgeniya Rodina.

[citation needed] Makarova started the 2009 season at Sydney where she lost in the first round to third seed and eventual champion, Elena Dementieva.

[13] Getting past qualifying at the Aegon International, she reached the quarterfinals where she was defeated by sixth seed and eventual champion, Caroline Wozniacki.

Makarova's career-best run at a Grand Slam tournament was ended in the fourth round by third seed and champion Kim Clijsters.

[citation needed] Makarova started at the Sydney International where she qualified, faced Li Na in the first round and lost.

[citation needed] Makarova defeated 16th seed Maria Kirilenko at the Madrid Open in the second round, before losing to Lucie Hradecká in the third.

[citation needed] Makarova reached the third round at the Cincinnati Open recording victories over Nadia Petrova and Anna Tatishvili, before losing to Samantha Stosur.

She partnered with Brazilian Bruno Soares to win the mixed-doubles competition, defeating Květa Peschke and Marcin Matkowski in three sets in the final.

In the doubles event, she teamed up with Elena Vesnina and won defeating Nuria Llagostera Vives and Sania Mirza in the final.

[citation needed] Makarova lost her openers in Indian Wells and Miami receiving first-round byes to Garbiñe Muguruza and Svetlana Kuznetsova, respectively.

She partnered Elena Vesnina in the doubles event at Indian Wells and won, defeating Nadia Petrova and Katarina Srebotnik in the final.

[23] She had reached the quarterfinals after defeating Marion Bartoli but then lost to seventh seed Sara Errani, in straight sets.

[25] Makarova began 2014 at the Sydney International, where she caused an upset by defeating fourth seed Jelena Janković in the first round.

Then, she reached the fourth round of the Australian Open for the third consecutive time but lost to eventual champion Li Na.

[citation needed] During the grass court swing, Makarova defeated Francesca Schiavone and Anastasia Pavlyuchenkova to book her place in the quarterfinals at the Eastbourne International.

At the Australian Open, she reached a Grand Slam semifinal second times in a row, crushing the third-ranked Simona Halep in two sets in the quarterfinal.

In doubles, Makarova and Vesnina made it into the quarterfinals, where they played against future champions Bethanie Mattek-Sands and Lucie Šafářová, and lost in three sets.

[citation needed] In January, Makarova took a break in doubles and started the 2016 season in the Premier tournaments Brisbane and Sydney, reaching the second round and quarterfinals, respectively.

Makarova also progressed in grass court in singles, winning six out of eight matches, only to lose against doubles partner Elena Vesnina in the fourth round.

Ekaterina had the worst possible luck at the US Open by drawing the number-one-player in the world, Serena Williams in singles to whom she lost in straight sets.

In her home country, she beat qualifier Nicole Gibbs in the first round, but lost to fellow Russian Daria Kasatkina in the second.

[34] She and Vesnina won their third joint and individual Grand Slam doubles title in Wimbledon, crushing runners-up Chan Hao-ching /Monica Niculescu, 6–0, 6–0.

[35] The Russian went on winning the Washington Open in singles, beating players as Olympic champion Monica Puig and world No.

[36] Makarova got into the third round of the Rogers Cup, defeating seventh-seeded Johanna Konta en-route but eventually losing to Lucie Šafářová.

[59] Competing in one more tournament before the final major of the year, she reached the quarterfinals at the Connecticut Open and lost to fifth seed Julia Görges.

During the 2014 Rogers Cup, Agnieszka Radwańska repeatedly targeted Makarova's forehand in the ad court, occasionally exposing it as a vulnerability.

[73] As of August 2017, Makarova was one of just two left-handed players (the other being Angelique Kerber) to have ever beaten Serena Williams in a Grand Slam match, doing so at the 2012 Australian Open.

[76] Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup and Olympic Games are included in win–loss records.