Coagulative necrosis

Coagulative necrosis is a type of accidental cell death typically caused by ischemia or infarction.

[1] It is believed that the injury denatures structural proteins as well as lysosomal enzymes, thus blocking the proteolysis of the damaged cells.

[3] Coagulative necrosis is most commonly caused by conditions that do not involve severe trauma, toxins or an acute or chronic immune response.

To achieve coagulative necrosis in tumor tissue, it only takes around 20 minutes of application with the RF probe.

[6] Additionally, high-intensity focused ultrasound (HIFU) also induces coagulative necrosis in target tumors.

Histopathology of a pheochromocytoma with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right).