In North America, the band played in many locations that they missed due to the cancellation of dates on their prior Guitar Hero Aerosmith Tour in 2009.

In addition, a drum solo by Joey Kramer occurred during the middle of the set, and at most concerts, Joe Perry performed a duel against the Guitar Hero: Aerosmith version of himself, like the previous year's Guitar Hero Aerosmith Tour, before performing a song in which he sang lead vocals (either "Stop Messin' Around", "Red House", or "Combination").

In the ensuing incident, the injured Perry threw down his guitar in anger while Tyler was checking to see if he was OK and stormed off the stage, but returned to finish the concert.

At the band's August 17 show at the Air Canada Centre in Toronto, Tyler playfully bumped Perry while both were performing the second song "Love in an Elevator" on the catwalk.

Tyler was previously injured in a fall off-stage in August 2009 which caused the rest of the band's Guitar Hero Aerosmith Tour to be canceled.