Throughout the series, Ned builds up a number of 'tips' for his "survival guide", and uses the tips to help himself and his classmates cope with the standard struggles of middle school.

Each individual episode relates to a topic in the guide, such as popularity, grades, or sports, as well as developing other plots (such as Ned's love life) throughout.

The first season of Ned's Declassified School Survival Guide was released on DVD in the Netherlands, Australia, and Belgium on April 9, 2009.

[13] In June 2008, Werkheiser signed a development contract with Nickelodeon for a spin-off that would deal with his character's adventures in high school.

[14] The show was never greenlit to production, due to the other major actors from the original series being busy with their own projects – creator and executive producer Scott Fellows was working on another Nickelodeon show, Big Time Rush; Daniel Curtis Lee was committed to Disney XD's Zeke and Luther; and Lindsey Shaw was working as the lead on ABC Family's 10 Things I Hate About You.